However, recently trifunctional NK cell engagers, which consisted of two antibody binding domains, one directed to a tumor associated antigen and one directed to NKp46, and the human Fc domain, showed enhanced cytotoxic properties, which suggests also a cooperation between NKp46 and FcγRIIIA and may be caused by additional factors, which remain to be uncovered (68). This evidence concerns the gene NCR1 and neoplasm.