TAC1 and rheumatoid arthritis: The Vamp-cleaving BoNT-protease is the most appropriate constituent of a potential therapeutic for treating RA due to Vamp3 and Vamp1 being essential for exocytosing cytokines and pain-peptides (such as CGRP and substance P etc), respectively, from the abovementioned proinflammatory cells and sensory neurons (44, 45).