Noteworthy, this TNF-α stimulatory effect did only occur upon exposure of HMECs to KTx-IgG from transplant patients with underlying vasculopathy, which has been shown to exhibit disturbed homeostasis in their blood/vasculature-resident RABs (1), but not upon exposure to healthy control IgG (Con-IgG), or KTx-IgG from patients without vasculopathy. This evidence concerns the gene TNF and vascular disorder.