Again, the above-mentioned study on SSc-IgG is exemplary to illustrate how binding of RABs to GPCRs, such as PAR1, can trigger secretion of proinflammatory cytokines, such as IL-6, or in the current KTx-IgG setting secretion of TNF-α from HMECs. The gene discussed is TNF; the disease is systemic sclerosis.