also demonstrated that monocyte/macrophages polarization toward M2 phenotype, LAMP3 + DC subgroup recruiting regulatory T cells, and inflammatory cancer-associated fibroblasts (iCAFs) in the tumor region, are all potentially implicated in the formation of an immune-suppressive TME and tumor progression, which are strongly correlated with poor prognosis of BC patients (61). This evidence concerns the gene LAMP3 and breast cancer.