MAD1L1 and Hypertension: Of the eight shared signals, three (near MAD1L1, GOLPH3L/HORMAD1 and at 17q21.31) had the same direction of effect on risk of IPF and raised blood pressure (hypertension) and five (near TERC, OBFC1, DEPTOR and at 7q22.1 and 6p21.2) had opposite effects, with the allele associated with increased risk of IPF being associated with decreased blood pressure (and vice versa for the other allele) (table 1).