As increased cellular and synaptic level E/I ratio in ASD can lead to increased neuronal excitability, epilepsy occurs in about 10% of people with ASD (Lukmanji et al., 2019) [about 15 times higher than incidence in the general population (Fiest et al., 2017)] and is particularly prevalent in individuals with NEXMIF mutations (Tye et al., 2019; Stamberger et al., 2020). Here, NEXMIF is linked to epilepsy.