Another study showed that Salvia miltiorrhiza and Carthamus tinctorius extract (SCE) effectively reduced myocardial fibrosis and inflammation by inhibiting H3K4me3 and H3K36 trimethylation (H3K36me3) at the Smad3 promoter in cardiac fibroblasts, leading to decreased Smad3 transcription (82). The gene discussed is SMAD3; the disease is Myocardial fibrosis.