PSEN2 and early-onset autosomal dominant Alzheimer disease: Most data suggest that the Alzheimer’s disease-related pathogenic cascade is more relevant than brain aging as patients who carry the APP, PSEN1 or PSEN2 gene mutations linked to autosomal dominant early onset Alzheimer’s disease have, if anything, a greater risk of seizures (∼28%) than those with later onset Alzheimer’s disease.5