Our previous in vivo data demonstrated the pain-mediating role of HK-1 in several acute and chronic orofacial, neuropathic, and inflammatory pain models (partial sciatic nerve ligation, acute, and chronic CFA and mast cell tryptase-induced, as well as K/BxN serum-transfer arthritis models) (Borbély et al., 2013, 2020; Aczél et al., 2018; Hunyady et al., 2019). The gene discussed is HK1; the disease is arthritic joint disease.