Furthermore, we observed consistent expression trends with GSE118553 of these genes in AD in GSE132903 (Figure 1D) (Supplementary Figures S1B,C) and found significant downregulation of Driver regulators such as KLF2 and YAP1 in AD, as well as significant upregulation of multiple Suppressor regulators (Figure 1E). The gene discussed is KLF2; the disease is Alzheimer disease.