CDK1 and glioblastoma: Notably, we identified a group of cells with active self-renewal and proliferation named MI-cycling with eight percent in total TAM cells (Supplementary Figure 2E), outside the conventional M1, M2, and DC classifications, which expressed high levels of Ki67 and CDK1, suggesting that the TAM system in the GBM brain was highly activated, though its effect on tumors needs further study.