Further alterations materialize in the form of amplified the phosphatidylinositol-3-kinase (PI3K) activity, pertaining to insulin receptor substrate-1 (IRS-1), and augmented type 4 glucose transporter (GLUT-4) translocation to the muscle surface, culminating in an augmented glucose uptake that serves to alleviate insulin resistance. The gene discussed is IRS1; the disease is Insulin resistance.