HMGB1 and Hyperglycemia: Furthermore, lncRNA H19 has been shown to serve as a sponge for miR-129 (137), and, positively regulate ion of high-mobility group box 1 (HMGB1) which modulates oxidative stress and hyperglycemia-induced ferroptosis in mesangial cells through the nuclear-related factor 2 (Nrf2) pathway (117).