Similarly, lncRNA PVT1 is up-regulated in DKD patients, and in vitro experiments explain that it encourages the recruitment of histone 3 lysine 27 trimethylation (H3K27me3) in the forkhead box A1(FOXA1) promoter region by recruiting enhancer of zeste homolog 2 (EZH2), which lessens FOXA1 expression, thereby increasing apoptosis and damage levels in podocytes (104). Here, FOXA1 is linked to diabetic kidney disease.