INS and Insulin resistance: A preclinical model demonstrated that cIH, which is the major feature of OSAS, is a critical component of glucose homeostasis disturbances, including insulin resistance characterized by decreased insulin sensitivity and increased HOMA-IR (homeostasis model assessment of insulin resistance), and dyslipidemia characterized by increased total cholesterol, LDL (low density lipoprotein), or triglyceride levels (6–11).