PCSK9 and systemic lupus erythematosus: There are studies reporting that higher proprotein convertase subtilisin/kexin type 9 (PCSK9, the gene associated with high LDL levels) levels correlate with SLE severity (Liu et al., 2020; Sánchez-Pérez et al., 2020), suggesting that blocking the PCSK9 function would be protective of SLE and its CVD risk.