The colocalization analysis showed that the posterior probability of colocalization between LDL and SLE in the HMGCR, PCSK9, and NPC1L1 gene regions was 1.65%, 50.4%, and 2.23% on the presence of a causal variant for the outcome, respectively, using the European population. This evidence concerns the gene NPC1L1 and systemic lupus erythematosus.