CASP3 and ovarian carcinoma: In a study on ovarian cancer, it was discovered that Tan-IIA deactivated the PI3K/AKT/JNK pathway to activate caspase-3, caspase-8, caspases-9 and downregulate Bcl-w, Mcl-1L, which led to cell apoptosis (Zhang et al., 2019b).