Similarly, in osteosarcoma, tanshinone I induced apoptosis of U2OS and MG63 cells targeting the circ_0000376/miR-432-5p/Bcl-2 axis, lowering circ_0000376 and Bcl-2 and elevating miR-432-5p (Ye et al., 2022). Here, BCL2 is linked to osteosarcoma.