In non-small-cell lung cancer, apoptosis of A549 and H292 cells was facilitated by tanshinone IIA through the circ_0020123/miR-1299/HMGB3 axis, which raised miR-1299 expression while decreased circ_0020123 and HMGB3 expression (Sun et al., 2023). The gene discussed is HMGB3; the disease is non-small cell lung carcinoma.