MYC and plasma cell myeloma: Moreover, a SNP in the c-Myc 5′UTR has been found to cause the overexpression of c-Myc in multiple myeloma (Chappell et al., 2000; Shi et al., 2016), and SNPs in the cis-acting regulatory motifs in the transcript leaders of connexin 32 and VEGFA has been linked to the development of two severe neurodegenerative disorders, the Charcot Marie Tooth disease and the amyotrophic lateral sclerosis (Hudder and Werner, 2000; Lambrechts et al., 2003).