Notably, targeting MUC4 or INHBA has shown effectiveness in suppressing PDAC malignancy.[33, 35] Furthermore, a recent study demonstrated that depleting Muc4 delayed PanIN initiation and PDAC formation in KPC mice.[36] In our study, we demonstrated that blocking Activin A signaling using FST could reduce fibroblast recruitment in early PanIN, leading to suppressed PanIN formation and growth in KC mice (Figure 6A to E). The gene discussed is FST; the disease is keratoconus.