Moreover, besides genetic changes, the microenvironmental changes mediated by oncogenic KRAS also play critical roles in cancer progression.[17] Studies on pancreatic injury have demonstrated that environmental alterations can collaborate with mutant Kras to accelerate early neoplasia and neoplastic transformation through epigenetic remodeling, indicating that gene‐environment interactions can influence neoplastic commitment.[18] However, the specific genetic and microenvironmental factors that cooperate with oncogenic KRAS to initiate the earliest PanIN formation remain largely unexplored. Here, KRAS is linked to cancer.