Notably, targeting MUC4 or INHBA has shown effectiveness in suppressing PDAC malignancy.[33, 35] Furthermore, a recent study demonstrated that depleting Muc4 delayed PanIN initiation and PDAC formation in KPC mice.[36] In our study, we demonstrated that blocking Activin A signaling using FST could reduce fibroblast recruitment in early PanIN, leading to suppressed PanIN formation and growth in KC mice (Figure 6A to E). This evidence concerns the gene INHBA and keratoconus.