Tumor evolves various mechanisms to occur immune escape, comprising impaired antigen presentation, activation of oncogenic signals, reduced responsiveness to IFN-\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\gamma$$\end{document}, and upregulated drug-resistance genes [57]. This evidence concerns the gene IFNA1 and neoplasm.