GRID2IP and neoplasm: The results showed that in T3&T4 stage subgroup (HR: 1.66; CI 1.14–2.40; P = 0.008), N1&N2 stage (HR: 1.68; CI 1.06–2.65; P = 0.026), Pathology Stage III & Stage IV (HR: 1.84; CI 1.16–2.91; P = 0.01) and Residual (R1&R2) tumor (HR: 2.36; CI 0.92–6.09; P = 0.075), the OS of the GRID2IP-high group were lower than those of GRID2IP-low subgroup (Fig. 7D–G).