Liu et al. [58] identified elevated levels of the lncRNA SOX2OT in TMZ-resistant cells and recurrent GBM patient samples and that it upregulated SOX2 expression by recruiting ALKBH5 to demethylate SOX2 transcripts, activate the Wnt5a/β-catenin signaling pathway, inhibit apoptosis, and promote cell proliferation and TMZ resistance. The gene discussed is SOX2; the disease is glioblastoma.