rRNA m7G methylation is facilitated by Williams-Beuren syndrome chromosome region 22 (WBSCR22) and tRNA methyltransferase activator subunit 11–2 (TRMT112) [142], while WBSCR22 fosters the glioma cell growth and metastasis by modulating the PI3K/AKT/GSK3β signaling pathway [143]. This evidence concerns the gene AKT1 and central nervous system cancer.