It was interesting to observe that HL217 was able to inhibit cell migration of DHLF-IPF even in the absence of TGF-β without CXCL12 (Fig. 6F) or with CXCL12 (Fig. 6H) as chemoattractant, possibly due to higher surface ENO1 expression if compared to NHLF (Fig. 6A-D). Here, CXCL12 is linked to idiopathic pulmonary fibrosis.