EDN1 and preeclampsia: Preeclampsia caused by placental hypoxia is due to endothelial dysfunction, which can be attenuated by the antioxidant and anti-inflammatory effects of irisin, as shown in rats with preeclampsia, where irisin decreases systolic blood pressure, diastolic blood pressure, ET-1, IL-6, MDA while increasing superoxide dismutase (SOD) levels, placental growth factor (PGF), and NO [122].