RARRES2 and hypertensive disorder: The overexpression of chemerin placental trophoblasts from mice causes a preeclampsia-like syndrome, hypertension, proteinuria, decreased trophoblast invasion, a disordered labyrinth layer, increased sFlt-1 and inflammatory markers (NFkB, TNF-α, and IL-1β), leading to growth restriction and reduced fetal weight in rats [54].