According to previous reports [6], the expression of p-S6K1 was significantly elevated in CRC tissue, and the expression level of inflammatory NLRP3 is positively correlated with the expression level of p-S6K1, which suggest that p-S6K1 may work together with inflammatory factors to induce tumor-initiating inflammation or stimulate cytokines by secreting growth or promoting tumor growth by mediating T cell inhibition. Here, NLRP3 is linked to neoplasm.