Lee HS found that the risk of MetS increased significantly only at an age of menarche < 12 years and higher levels of triglycerides; the genome-wide association studies (GWAS) pathway, which contained amino-terminal kinase level pathways and stress-activated protein kinase signals, were also found to be associated with increased triglyceride levels among women with earlier menarche [66]. This evidence concerns the gene WEE1 and metabolic syndrome.