In teleosts, NLRC3 genes were highly expressed in sevenband grouper (Epinephelus septemfasciatus) spleen and attenuated the interferon response by impacting TRAF6/NF-κB activity and reducing IFN sensitivity, ISRE promoter activity, and IFN pathway gene expression after viral infection, but increased the inflammasome response and pro-inflammatory gene expression [72]. The gene discussed is NFKB1; the disease is viral infectious disease.