In addition, NLRC3 silencing may play an important role in cancer progression and prognosis of hepatocellular carcinoma via the activation of Janus kinase 2/signal transducers and the transcription 3 (JAK2/STAT3) pathway under interleukin-6 (IL-6) stimulation [80, 81]. Here, JAK2 is linked to hepatocellular carcinoma.