On the contrary, other studies found non-significant difference between the levels of 25(OH)D in the MHO and the MUO [50, 51], in spite of the reported inverse associations between the levels of 25(OH)D and triglycerides levels, insulin resistance and blood pressure [50], this could be explained by differences in the degree of obesity or in the criteria used for defining metabolic health. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.