AKT1 and Hepatic fibrosis: AuNPs migrate to the Kupffer cell nucleus where they negatively modulate cytokine release and modulate the pathways of phosphatidylinositol 3-kinase/AKT and mitogen-activated protein kinases that play an essential role in the occurrence and development of liver fibrosis by controlling the degradation of collagenous extracellular matrix and activation of HSC [62, 65].