Also, the mRNA levels of CEACAM1 and CEACAM6 (known membrane markers of malignant epithelial cells in various adenocarcinoma, including colon cancer30,31), as well as MKI67 (a proliferation marker), were significantly higher at tumor center and tumor invasive margin than adjacent normal in PanCK(+) AOIs (Supplementary Fig. 9g–i). This evidence concerns the gene CEACAM1 and adenocarcinoma.