CD8A and paracoccidioidomycosis: T cell dysfunction scores trended toward higher in MBM relative to PCM (p = 0.08; Fig. 2d), and among tumors with non-zero CD8 + T cell infiltration, the percentage of tumors with transcriptomic signatures indicating non-functional CD8 + T cells was significantly lower among MBM (p < 0.0001; non-functional CD8 + T cells were defined by high dysfunction scores [composite z-score >1.0] but low FGFBP2 mRNA levels [less than median TPM for cohort]; Fig. 2e).