A positive association was observed between composite STING scores (comprising mRNA levels of key regulators of the STING pathway [TMEM173, CGAS, CCL5, CXCL10 and IRF3]), computationally inferred CD8 + T cell infiltration, and T cell dysfunction scores among all melanoma tumors (p < 0.0001; Supplementary Fig. 3a–c) and among each anatomic site (p < 0.0001; Supplementary Fig. 3d). The gene discussed is IRF3; the disease is melanoma.