Among the 27 hub genes (ACTN2, TPM2, FLNC, MYH11, ITGA7, DMD, PAK3, LMOD1, GNAI1, MYLK, PLN, CTPS1, CNN1, MYH10, NLGN1, ADAMTSL3, MYOCD, MICU3, PPP1R14A, MAP2, OGN, PDE8B, RGS5, MAP1B, ITGA9, AKAP6, and SMTN) identified in this study, ACTN2, as pointed out earlier13, is a hub gene related to heart failure. This evidence concerns the gene MYH11 and heart failure.