TNC and cancer: Since TNC was only present in the U251 IP but not in the non-cancer HEK293 interactome, and given that TNC expression is up-regulated by NF-κB in the aggressive mesenchymal subtype of GBM [23, 24] and associated with unfavorable prognosis in multiple cancers (Supplementary Fig. S2A, B), we next explored the functional links between TNC, PTP1B and NF-κB.