Finally, using the Human Protein Atlas dataset, overall survival (OS) analyses showed a significant association between high expression of SHN3 and MMP9 and poor prognosis in glioma (p values: 0.012 and 0.0084, respectively; while SHN3, IL13Rα2 and MMP9 expression were also associated with poor OS in the thyroid (p-value: 0.011, 0.0097) and renal (p-value: 2.8E-9, 1.5E-5) cancers (Supplementary Fig. S8). Here, MMP9 is linked to central nervous system cancer.