Here, we identified a close association of PTP1B with different proteins of the NF-κB signaling pathway together with a novel mechanism involving the activation of the transcription factor Schnurri-3 (SHN3), to promote cancer cell growth and invasion by activating the Wnt-β-catenin pathway and the expression of matrix metalloprotease 9 (MMP9). This evidence concerns the gene NFKB1 and cancer.