Pattern 3 consisted of 120 SVGs and enrichment in apoptosis activity (q-value 7.31e-06) and complement activation process in the pathogenesis of RA (q-value 1.96e-05), supported by genes such as C1S, C1R, C1QC, S100A8, and S100A953. Here, C1R is linked to rheumatoid arthritis.