To this end, we used the Pten model of epilepsy because (a) Pten fb-KO mice develop spontaneous recurrent seizures and (b) genetic inhibition of mTORC2 (Pten-Rictor fb-DKO), but not mTORC1 (Pten-Rptor fb-DKO), reduced seizures arising from Pten deficiency23. Here, PTEN is linked to epilepsy.