BCL2 and gastric cancer: In addition, the anti-apoptotic protein Bcl-2 can interact with the autophagy protein beclin-1 and the disruption of the interaction between Bcl-2 and beclin-1 contributes to autophagy.34–36 The co-immunoprecipitation assay showed that when gastric cancer cells were exposed to microcolin H for 6 h, the complex of beclin-1 and Bcl-2 significantly reduced (Fig. 6c).