PTCH1 has been reported to overexpressed in human advanced atherosclerotic lesions, especially in CD68 positive macrophages [18], while in the atherosclerotic plaques from apoE−/− and LDLR−/− mice with high-fat diet, HHIPL1, which plays a positive role in Hh signaling pathway activation, is overexpressed in VSMCs of plaque and accelerates atherogenesis in the early stage of atherosclerosis [19]. The gene discussed is APOE; the disease is atherosclerosis.