Importantly, the effect of LASS2 overexpression on the expression of p53 downstream EMT targets (Slug, N-cadherin, and vimentin) in WT p53 and mutant p53 hepatoma cell lines (P < 0.05, Fig. 4E, F and Fig. S2F) was also found to be attenuated by the p53 inhibitor PFT-α. This evidence concerns the gene SNAI2 and hepatocellular carcinoma.