As shown in Fig. 6A, B, using the Kaplan–Meier Plotter database (MDM2 DFS: Hazard ratio [HR] = 2.1, P = 0.0018; MDMX DFS: HR = 1.8, P = 0.012), multivariable analysis for Disease Free Survival (DFS) determined that high MDM2 or MDMX expression is associated with shorter DFS in liver cancer patients. This evidence concerns the gene MDM4 and liver cancer.