TP53 and cancer: In the TCGA database, SFRP1 was downregulated in breast cancer compared to healthy regardless of individual cancer stages (Figure 7A), race (Figure 7B), nodal metastasis status (Figure 7C), tumor histology (Figure 7D), major subclasses (Figure 7E), menopause status (Figure 7F), and TP53 mutation status (Figure 7G).