VEGFA and hypertensive disorder: The possible reason could be due to the fact that in cases of diabetes mellitus and multiple pregnancies cause an increase in placental mass or hypoxia of the placenta that possibly leads to the secretion of antiangiogenic factors like; tyrosine kinase 1 and endoglin sEng that antagonize placental growth factors and vascular endothelial growth factors result in hypertension, protein and maternal syndromes [2, 40].