Finally, the most important biomarkers (FNI >0.01) for cardiovascular death or hospitalization for HF were conveyed by NT-proBNP, hs-TnT, trefoil factor 3 (TFF3), VEGF-D, IL-6, and REN while SCF, ADM, and osteopontin (OPN), were associated with reduced risk. The gene discussed is REN; the disease is hydrops fetalis.