The CVD-21 model achieved slightly lower c-indices for all events, from 0.63 for MI to 0.66 for MCE and 0.83 for HF, clearly showing that this was dependent on the inadequate sensitivity of troponin I (Fig 3). For comparison, for CV-death the ABC-CHD risk score achieved similar c-index as the CVD-21 models that included hs-cTnT. This evidence concerns the gene TNNT2 and coronary artery disorder.