Vitamin D deficiency can cause a decrease in 1,25-OHD, insulin secretion, insulinreceptor and an increase in insulin sensitivity, inflammation and oxidative stress.Vitamin D deficiency can also result in a decrease in SHBG and an increase intestosterone levels, leading to hyper-androgenism, hirsutism and acne. The gene discussed is SHBG; the disease is Hirsutism.