WNK2 and skin carcinoma: Previous evidence showed that epidermal cells might activate phosphoinositide-3-kinase/protein kinase B (PI3K/Akt) and mitogen-activated protein kinase (MAPK) signaling pathways with stimulation of UV, which phosphorylates downstream substrated and could ultimately cause skin carcinoma (Chaiprasongsuk and Panich 2022).