TP53 and melanoma: Furthermore, by establishing animal models that mimicked mild sunburn in humans, Viros et al. (2014) found that mutant Trp53, an accepted UVR target in human non-melanoma skin cancer, could accelerate BRAF (V600E)-driven melanomagenesis and that TP53 mutations are linked to evidence of UVR-induced DNA damage in human melanoma, which provided a possible molecular insight into how UVR accelerates melanomagenesis.