As represented in Fig. 1A, hepatic tissues of NASH rats showed marked increase in p65 NF-κB expression with drastic raise in the hepatic levels of IL-1β, IL-6, and TNF-α (Fig. 1B) as compared to the normal group (P < 0.001). The gene discussed is NFKB1; the disease is metabolic dysfunction-associated steatohepatitis.