To provide an unbiassed selection to study, we decided to analyse all mis-sense mutations in the PRKAA1 (encoding AMPK-α1) and PRKAA2 (encoding AMPK-α2) genes that had been reported to occur in melanoma and non-melanoma skin cancer in the cBioPortal database at the time of commencement of our study in 2019. This evidence concerns the gene PRKAA2 and skin neoplasm.