PRKAA1 and non-small cell lung carcinoma: In mouse models of non-small cell lung cancer induced by mutations in K-Ras and/or p53, simultaneously knocking out both AMPK-α1 and -α2 was reported to either exacerbate [35–37] or ameliorate [38] the disease, although more prominent effects, similar to those obtained by knocking out LKB1, were obtained by knocking out the AMPK-related kinases SIK1-3 [37,39].