OPG expression has been suggested as an evasion mechanism from TRAIL‐induced apoptosis acquired by activated myofibroblasts in liver fibrosis (Habibie et al, 2021), and the expansion in signaling to SMC‐like cells through this pathway from PA to TGF‐β1 treatment suggests the gradual acquisition of fibrogenic activation in these myofibroblast‐related cells. This evidence concerns the gene TNFRSF11B and Hepatic fibrosis.