APP and Alzheimer disease: Of note, AD is a chronic and progressive brain disorder that slowly destroys memory, thinking and behavior, although we have identified the 12-month-old APP/PS1-P2Y1KO mice exhibited reduced amyloid beta protein, inhibited glial activation, decreased fibrinogen aggregation along the vessel and better behavior tests, the long-term effects of astrocytic P2Y1R on AD progression remains uncertain.