However, the ECF-Zn in control mice increased 3-fold during the later phase of ischemia (75-120 min MCAO), whereas ECF-Zn in ZnT3-cKO mice only had a marginal change, suggesting that neuronal-specific ZnT3 knockout prevented free zinc release from neurons during cerebral ischemia. Here, SLC30A3 is linked to Cerebral ischemia.