SLC30A3 and brain ischemia: In this study, utilizing cellular and animal models of ischemic stroke, including transgenic mice with ZnT3 specifically knockout in neurons, we determined whether ECF-Zn contributes to BBB damages during cerebral ischemia, and investigated both the source of high levels of ECF-Zn and the mechanism by which ECF-Zn mediates ischemia-induced BBB damage.