In particular, a number of studies that studied populations of different countries have resulted in the discovery of several associations between specific genes and POAG including CDKN2B-AS1, TMCO1, CAV1/CAV2, SIX1/SIX6, ABCA1, TGFBR3, and many other additional loci, [28] although detailed discussions of each are beyond the scope of this review. The gene discussed is CAV1; the disease is open-angle glaucoma.