SH2D3A and viral infectious disease: In the context of SARS-CoV-2 infection, BIN1 has been shown to hinder viral infection through the following mechanisms: i) BIN1 may disrupt viral infection by interacting with SARS-CoV-2 NSP1; and ii) by binding to NSP3, BIN1 could potentially interfere with the conformational changes of this viral protein, therefore limiting the release of newly synthesized viral RNA [69].