For example, Telmisartan treatment dose-dependently improves AIS-induced NLRP3 inflammasome activation in hypertensive rats, significantly reduces amyloid-β deposition in neurons, and may have a preventative effect on the development of Alzheimer's disease pathology in the brain by alleviating the NLRP3 inflammasome after AIS [161, 163]. This evidence concerns the gene NLRP3 and early-onset autosomal dominant Alzheimer disease.